Genetic genocide: Genetically altered mosquito warriors could wipe out humanity’s biggest killer

by Rebecca on December 3, 2011

in Pet Talk

By Loz Blain


War, plague, famine, heart disease, cigarettes, road trauma: six very effective  killers of human beings. But they’re all amateurs when their records are  compared to the number one mass murderer of all time. The humble mosquito, and  the deadly diseases it carries, is estimated to have been responsible for as  many as 46 billion deaths over the history of our species. That staggering
number is even more frightening in context – it means that mosquitoes are alleged to have killed more  than half the humans that ever lived.

So if any creature has earned the full force of the wrath of humanity, this nasty  little bugger is it. Especially certain species like Aedes aegypti mosquitoes  – the world’s number one disease vector for deadly dengue fever, which infects  between 50 and 100 million people a year around the world.

A. aegypti has evolved into the most curious and innocuous of human predators –  it’s the females that bite, and they more or less only feed on humans. Each  bite exposes the victim to any blood-borne pathogens that the mosquito might  have picked up along its way. Dengue and yellow fevers are among the most  common – the mosquito contracts the virus by biting an infected victim, and  then injects it along with its saliva when it stabs the next unlucky target’s  skin with its proboscis.

A. aegypti flies silently, so it’s hard to know when you’re in danger of being bitten, and it breeds and multiplies extremely  effectively, needing only a  teaspoon full of standing water for its larvae to hatch.

DDT-based insecticides have been effective against these little blighters, but evolution  is quickly building up their resistance to this and other control measures. Fighting them with poison might be  effective in the short term, but in the long run it only makes them stronger.

There is, however, a potential solution that can hijack the mosquito’s breeding cycle to dramatically bring down the population and human risk factors. And it’s  undergoing testing in two very different ways right now.

Genetic hacking – a brilliant solution

American scientist Anthony James, from UC Irvine, has made mosquito genetics the focus of his career – and his latest invention is a genetically modified mosquito designed to bring populations of Aedes aegypti down from within. In short, the modified genes affect only the female mosquitoes, rendering them  flightless. The larvae hatch on the water, and the females are unable to leave,
rendering them harmless to humans and leaving them to die. The males are unaffected, so they mature normally, then mate with other females to pass the genetic modification on.

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